Usmle mcq questions series 2

10 multiple-choice questions (MCQs) designed for the USMLE (United States Medical Licensing Examination):


  1. A 55-year-old man presents with a history of progressive shortness of breath and a chronic productive cough. He has a 40 pack-year smoking history. Physical examination reveals decreased breath sounds and hyperresonance to percussion. What is the most likely diagnosis?
    • A) Asthma
    • B) Bronchiectasis
    • C) Chronic Obstructive Pulmonary Disease (COPD)
    • D) Pulmonary Fibrosis
    • E) Congestive Heart Failure
  2. A 25-year-old woman presents with fever, malaise, and a maculopapular rash that started on her face and spread to her trunk and extremities. She also has tender postauricular lymphadenopathy. Which of the following is the most likely diagnosis?
    • A) Measles
    • B) Rubella
    • C) Varicella
    • D) Roseola
    • E) Scarlet Fever
  3. A 60-year-old woman with a history of hypertension presents with sudden-onset severe headache, vomiting, and loss of consciousness. Her blood pressure is 220/130 mmHg. A CT scan of the head shows a hemorrhage. What is the most likely location of the hemorrhage?
    • A) Epidural space
    • B) Subdural space
    • C) Subarachnoid space
    • D) Intraparenchymal
    • E) Ventricular system
  4. A 32-year-old woman presents with fatigue, weight gain, constipation, and cold intolerance. Physical examination reveals dry skin and a delayed relaxation phase of deep tendon reflexes. Which of the following is the most likely diagnosis?
    • A) Hyperthyroidism
    • B) Hypothyroidism
    • C) Addison's disease
    • D) Cushing's syndrome
    • E) Pheochromocytoma
  5. A 45-year-old man presents with chest pain that occurs at rest and is relieved by nitrates. His ECG shows transient ST-segment elevation during episodes of pain. Which of the following is the most likely diagnosis?
    • A) Stable angina
    • B) Unstable angina
    • C) Myocardial infarction
    • D) Prinzmetal's angina
    • E) Pericarditis
  6. A 70-year-old man with a history of chronic kidney disease presents with fatigue, pallor, and decreased exercise tolerance. Laboratory studies reveal a hemoglobin level of 8 g/dL. Which of the following is the most likely cause of his anemia?
    • A) Iron deficiency
    • B) Vitamin B12 deficiency
    • C) Anemia of chronic disease
    • D) Hemolytic anemia
    • E) Aplastic anemia
  7. A 5-year-old boy presents with a 3-day history of fever, sore throat, and difficulty swallowing. Physical examination reveals an erythematous pharynx with tonsillar exudates and tender cervical lymphadenopathy. What is the most likely causative organism?
    • A) Streptococcus pyogenes
    • B) Haemophilus influenzae
    • C) Epstein-Barr virus
    • D) Mycoplasma pneumoniae
    • E) Candida albicans
  8. A 40-year-old woman presents with polyuria, polydipsia, and polyphagia. Her fasting blood glucose level is 250 mg/dL. Which of the following is the most likely diagnosis?
    • A) Diabetes mellitus type 1
    • B) Diabetes mellitus type 2
    • C) Diabetes insipidus
    • D) Syndrome of inappropriate antidiuretic hormone (SIADH)
    • E) Hyperthyroidism
  9. A 30-year-old man presents with a painless, enlarged cervical lymph node. He reports night sweats, fever, and unintentional weight loss over the past 2 months. A lymph node biopsy shows Reed-Sternberg cells. What is the most likely diagnosis?
    • A) Non-Hodgkin lymphoma
    • B) Hodgkin lymphoma
    • C) Metastatic carcinoma
    • D) Tuberculosis
    • E) Sarcoidosis
  10. A 3-year-old girl is brought to the emergency department with a high fever, drooling, and difficulty breathing. On examination, she is sitting forward with her neck extended and appears anxious. What is the most appropriate next step in management?
    • A) Administer oral antibiotics
    • B) Obtain a throat culture
    • C) Perform a neck X-ray
    • D) Secure the airway
    • E) Prescribe corticosteroids


  1. C) Chronic Obstructive Pulmonary Disease (COPD)
  2. B) Rubella
  3. D) Intraparenchymal
  4. B) Hypothyroidism
  5. D) Prinzmetal's angina
  6. C) Anemia of chronic disease
  7. A) Streptococcus pyogenes
  8. B) Diabetes mellitus type 2
  9. B) Hodgkin lymphoma
  10. D) Secure the airway

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